The dietary changes in today’s world have had a huge impact on the health of the general public. Research from the past already shows that the daily intake of a person plays a major role in the body. It can both prevent or raise the risk of a specific health condition. For instance, one of such issues is insulin resistance.
Metabolic diseases are one of the main global pandemics. There are a lot of factors that can lead to the development of such a health condition. Some of these include not getting enough exercise and a high intake of sugar.
Typically, many of the metabolic diseases begin with the person getting insulin resistance. One of the most dangerous outcomes of the body becoming resistant to insulin is diabetes. Statistically, diabetes affects millions of people in the United States alone.
Currently, more and more people are developing insulin resistance. According to researchers, this may be a result of the rise in cases of obesity. However, scientists are not clear about what exactly leads to metabolic conditions while having obesity.
Therefore, researchers from the University of Toronto further explore the issue. More specifically, they focus on the impact of having high-fats in daily intake.
Additionally, they also looked at the changes caused by such a diet in gut bacteria as well as immunity. The findings of the study appear in the journal Nature Communications.
What Was the Research Method?
At the moment, the main issue with controlling health diseases is that they are much more complicated. Secondly, a lot of factors come into play in the development of a particular condition. For instance, being overweight or obese increases the risk of metabolic disease and many other problems as well.
In consonance with previous research, it may also cause heart disease and liver-related issues. Similarly, diet plays a fundamental role in obesity and further development of such problems.
In the new research, the researchers look at a particular molecule – immunoglobulin A or IgA. This molecule is actually an antibody which is produced by the B immune cells. They choose IgA because it is a connection between the intestinal immunity and bacteria in the gut.
According to researchers, looking at IgA may explain the link between poor diet and insulin resistance. Therefore, they looked at mice who had obesity and low-levels of IgA molecule in their intestines. These mice were then given a high-fat diet.
After doing so, the researchers noted that the mice became even more resistance to insulin. In the second step of the study, new rodents without gut bacteria had a transplant from the obese mice. Consequently, the new lab rodents also developed insulin resistance.
Conclusively, the researchers state that this shows the levels of IgA molecules have a significant effect. Not only did they decrease the risk of insulin problems but also prevented intestine permeability. This means that harmful bacteria from the gut did not make their way into the rest of the body with enough IgA.
What Was the Final Result?
After seeing results in mice, the researchers moved to humans. For doing so, they examined stool samples from people who had had bariatric surgery which is an operation for weight loss. The main focus was on the levels of IgA in the samples.
After the examination, it was found that there were higher levels of IgA after the people had undergone the surgery. This shows the importance of having a balanced diet. In the future, there may be a way to boost IgA levels but the best method is always prevention.