Research reveals that negative mood signals the immune response of the body

The recent study reveales that negative mood, like sadness and anger, is associated with higher levels of inflammation. Also, it may be a sign of poor health, according to research. This study was published in the journal Brain, behavior, and immunity.

Frequent negative attitudes are a sign that stress is going to have a harmful effect on you. You may be facing personal exhaustion.

The scientists discovered that negative mood, measured several times a day over time, is linked to higher levels of inflammatory biomarkers. Hence, this extends preceding research which demonstrates that clinical despair and anger are related to higher inflammation.

Inflammation is part of the body’s immune response to different issues. For example, infections, wounds and tissue damage. Chronic inflammation can cause many ailments and conditions, comprising diabetes, cardiovascular disease, and cancer.


Nearly 220 participants were involved in the study. Data of participants was generated from an ongoing study named as the “Effects of Stress on Cognitive Aging, Physiology, and Emotions” (ESCAPE) Study.

Participants were socio-economically, racially and culturally diverse. Participants were asked to recall their emotional state over a period of time. Also, they were asked to report how they were feeling in the moment, in daily life.

These self-valuations were taken over a period of two weeks. Then each was trailed by a blood draw to measure markers which indicated inflammation.


The investigators observed that negative mood gathered from the week closer to the blood draw was related to higher inflammation levels.

Chief investigator Jennifer Graham-Engeland said, “Further analyses also proposed that the timing of mood measurement relative to the blood collection mattered. Particularly, there were stronger association trends between short-term negative effects and inflammation when the negative mood was measured closer in time to a blood draw.”

“This effort is innovative because investigators not only used surveys which asked participants to recall their moods over a period of time, they also questioned participants how they were feeling in the instant.”

Moreover, momentary positive mood was associated with lower levels of inflammation from the same week, but only among men.

This research was cross-sectional, Graham-Engeland said. Several studies were experimental and will require repetition. These outcomes stimulate ongoing research to examine how daily life intervention can improve mood and help people deal with stress.

Graham-Engeland said, “We expect that this study will enable researchers to include momentary measures of stress and effect in research to examine inflammation, replicate current findings. And help describe the mechanisms underlying associations between affect and inflammation.”

“As the effect is variable, we are happy about these results. And hope that they will spur further research to understand the link between effect and inflammation.

This, in turn, may help novel psychosocial interventions that promote health largely. It may also help break a cycle which can lead to chronic inflammation, disability, and disease.”

Areeba Hussain

Areeba is an independent medical and healthcare writer. For the last three years, she is writing for Tophealthjournal. Her prime areas of interest are diseases, medicine, treatments, and alternative therapies. Twitter @Areeba94789300

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