Niacinamide: Benefits and Side Effects

Niacinamide also termed nicotinamide, is one of the two forms of vitamin B3 — the other is nicotinic acid. Vitamin B3 is also recognized as niacin.

Niacinamide and nicotinic acid both develop activity of vitamin B3, but they vary in structure and how they affect health. A deficiency of B-3 can lead to disorders of the brain, skin, and kidneys. Taking niacinamide can prevent B-3 deficiency.

Niacinamide is found in various foods such as meat, yeast, fish, milk, green vegetables, eggs, beans, and cereal grains. It is also found in many vitamin B complexes complements with other B vitamins. Niacinamide can also be made from dietary niacin in the body.

What Is Niacinamide?

Niacinamide is a form of vitamin B3 which is one of the eight B vitamins your body requires for good health. Vitamin B3 plays an important role in the conversion of the food you consume into usable energy. Thus helping your body’s cells to carry out vital chemical reactions.

As it is water-soluble so you can’t store this vitamin that is why you must eat niacinamide daily. Vitamin B3 is usually found as niacinamide in animal-based produces, like meat and poultry. It is found as the nicotinic acid in plant-based products such as seeds, nuts, and green vegetables.

Several refined grain foods, including cereals, are also stimulated with niacinamide. Your body can make vitamin B3 from tryptophan, an amino acid found in most protein foodstuffs. However, the change of tryptophan to vitamin B3 is unproductive, as 60 mg of tryptophan is required to make just 1 mg of vitamin B3. Traditionally, vitamin B3 was so-called vitamin PP, an abbreviation for pellagra-preventive.

That is because tryptophan or vitamin B3 deficiency can cause a disease called pellagra. It is characterized by the four D’s — dermatitis, dementia diarrhea, and if left untreated, death. Pellagra is uncommon in advanced countries like North America and Europe, but the disease is still common in some emerging countries.

Niacinamide and nicotinic acid can both treat pellagra, but niacinamide is chosen because of its fewer side effects, like flushing of the skin.

Benefits and uses

Aside from being chosen for treating pellagra, niacinamide has various other health benefits.

Helpful for certain skin conditions

Niacinamide is a popular additive in the skincare products as it plays a vital role in keeping your skin fresh and healthy. It can help your skin produce a ceramide (lipid) barrier, which can help maintain moisture.

Niacinamide has anti-inflammatory effects on the skin when taken orally as a supplement or applied topically. It is mostly used to treat skin disorders like acne and rosacea, a facial skin illness characterized by soreness. Therefore, niacinamide used as an alternative to topical or oral antibiotics for the treatment of acne or rosacea.

May help prevent melanoma

Melanoma is a serious skin cancer which develops in the melanin-producing cells. Melanin is the pigment that gives color to your skin. Ultraviolet (UV) radiation exposure, from the sun or tanning beds, damages the DNA of cells over time and is intensely linked with melanoma.

Due to its role in keeping your cells fit, its oral supplements have been shown to improve DNA repair in UV impaired skin in humans. Naturally, niacinamide is a favorable supplement which may provide protection against melanoma, particularly in populations with high-risk, like those who have had prior nonmelanoma skin diseases.

Useful for chronic kidney disease

Chronic kidney disease is the great loss of kidney functioning which affects the ability of your body to clean and filter blood and also control blood pressure. This can cause a damaging accumulation of chemicals in your blood, like phosphate.

The study proposes that niacinamide may help reduce phosphate levels in persons with kidney dysfunction by hindering its absorption. Phosphate levels are then normally managed through nourishment, medicines or dialysis. It all depends on the severity of the buildup or disease.

May slow the progression of Type 1 Diabetes

In Type 1 diabetes your body attacks and then destroys the normal insulin-producing beta cells of the pancreas. It’s been proposed that niacinamide preserves and protects your beta cells. Thus delaying or preventing the inception of type 1 diabetes in at-risk persons.

But, recent research doesn’t support the idea that niacinamide can stop the onset of this disease, though it may help delay the disease progression by stabilizing the function of beta cells. But still, more study is required before niacinamide supplements can be commended as a mediation for type 1 diabetes.

Supplement types and forms

Vitamin B3 in the form of niacinamide is usually used as a dietetic supplement. Vitamin B3, as niacinamide or nicotinic acid, is accessible as a supplement either by itself or together with other minerals and vitamins in dosages ranging from 14 to 1,000 mg per portion.

The vitamin is also incorporated in B-complex supplements that cover all eight B vitamins. Some supplements which have vitamin B3 only list niacin, but maximum supplements state the niacin form as either niacinamide or nicotinic acid.

Niacinamide may be involved in pre-workout supplements, but nicotinic acid, which causes skin flushing, is chosen for the purpose of giving the customer an intellect that the pre-workout has kicked-in subsequent the flushing of the skin. For skin care, niacinamide is frequently incorporated in facial moisturizing lotions or in other products sold for treating acne or rosacea.

Side effects

Niacinamide is mostly well-tolerated in suitable doses, basically because surplus amounts of it are excreted with urine.

The acceptable higher limit of vitamin B3 is 35 mg per day. This is the least amount probable to cause redness, flushing, itching, and tingling of your skin. These are the known side effect of nicotinic acid but not niacinamide.

There have been accounts of insignificant side effects connected with nicotinamide, like nausea, stomach discomfort, and headaches. It has also been commended that nicotinamide may raise insulin resistance, a symbol of type 2 diabetes, but the confirmation has been unreliable. Therefore, it’s best to consult with your doctor before adding with niacinamide — or any supplement for that matter — to measure your individual risk.

The bottom line

Niacinamide is the form of vitamin B3 (niacin) which plays a very important role in cell death and energy metabolism. It may offer welfares linked to skin care and skin cancer, as well as type 1 diabetes and chronic kidney disease.

Niacinamide is largely deliberated safe with rare side effects at proper doses. It’s obtainable as a dietary supplement and also a common ingredient in skin care items. Still, consult with your healthcare provider before trying niacinamide or any other supplement.

Ilene Johnstone

Ilene Johnstone is an author at Top Health Journal. Currently, she is working as a biochemist and researcher. She is keen on emerging research, diet, new treatments, diseases and other trending topics in health. She delivers best regarding health to viewers in the form of interesting writings. Twitter- @IleneJohnstone

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